MTP inhibition induces ER stress and increases gene transcription via Ire1α/cJun to enhance plasma ALT/AST

Abbreviations used: ALT, Alanine aminotransferase; ApoB, Apolipoprotein B; AST, Aspartate aminotransferase; ER, Endoplasmic Reticulum; GPT, Glutamic Pyruvic Transaminase; GOT, Glutamic Oxaloacetic Transaminase; GSH, Reduced glutathione; HDL, High density lipoprotein; HMGR, HMG-CoA reductase; LDH, lactate dehydrogenase; Lo, Lovastatin; MTP, Microsomal triglycerides transfer protein; MTPi, MTP inhibitor; p-eIF2α, phosphorylated-eukaryotic Initiation Factor 2α; PBS, phosphate buffered saline; PI, propidium iodide; Pio, Pioglitazone; pIRE1α, phosphorylated-Inositol require enzyme 1α; PPAR, Peroxisome proliferator-activated receptor; p-PERK, phosphorylated-Protein kinase like-endoplasmic reticulum kinase; WDF, Western diet fed; XBP-1, Xbox binding protein-1; PM, plasma membrane; ER, endoplasmic reticulum; Mito & Peri, mitochondria and peroxisomes;